Polynucleotides - is the hype right?

Polynucleotides in Mesotherapy: A Clinically Focused Overview

From Julia Howard Skin Clinic

At Julia Howard Skin Clinic we prioritise evidence-based, medically sound treatments that improve skin quality at a structural level, not just cosmetically mask signs of ageing. Polynucleotide mesotherapy is one such treatment that’s gaining traction in professional aesthetic practice because it works with your biology — not against it — to address ageing and skin damage.

What Are Polynucleotides?

Polynucleotides (often referred to clinically as PNs or polydeoxyribonucleotides when derived from DNA fragments) are long chains of nucleotides — the basic building blocks of DNA. In aesthetic medicine these are highly purified, biocompatible molecules that act as biostimulators when delivered into the skin. 

Unlike traditional fillers, which add volume, or superficial hydrating injectables, polynucleotides penetrate into the dermal layer to support natural cellular repair and regeneration. 

How Polynucleotide Mesotherapy Works

Mesotherapy involves micro-injections into the mesoderm (the mid-layer of the skin) to deliver active substances where they can exert a biological effect. In the case of polynucleotide mesotherapy:

• Cellular regeneration is stimulated. Polynucleotides enhance the activity of fibroblasts — the cells responsible for producing collagen and elastin — improving structural support in the dermis.  

• Hydration improves at a deep level. These molecules attract and retain water within the skin, contributing to sustained hydration.  

• Anti-inflammatory and reparative effects support tissue recovery. This reduces irritation and promotes healthier skin turnover.  

The result is a gradual, biologically driven improvement in skin quality rather than an immediate surface fix. 

Clinical Benefits You Can Expect

While individual responses vary, emerging clinical evidence and practitioner experience suggest polynucleotide mesotherapy can:

• Improve skin texture, elasticity and firmness.  

• Reduce the appearance of fine lines and wrinkles with ongoing stimulation of collagen and elastin.  

• Enhance hydration and radiance for a healthier complexion.  

• Support recovery and healing after resurfacing or other procedures due to regenerative properties.  

• Aid in smoother, more even skin tone and texture over a course of treatments.  

These effects typically develop over weeks as the skin responds to the treatment stimulus rather than being instantly visible. 

How It Fits Into a Treatment Plan

Polynucleotide mesotherapy isn’t a standalone “quick fix.” It’s best integrated into a comprehensive regenerative protocol tailored to your skin quality and aesthetic goals.

A typical approach may include:

• Initial course of 2-3 sessions spaced 2–4 weeks apart.  

• Maintenance treatment every 6–12 months to sustain collagen stimulation.  

• Adjunctive procedures such as microneedling, laser resurfacing or professional skincare to maximise outcomes.

Safety and Expectations

When performed by trained clinicians using medical-grade products, polynucleotide mesotherapy has an excellent safety profile with minimal downtime. Mild redness or tenderness can occur but typically resolves quickly. 

It’s essential to have a full consultation to assess suitability, set realistic expectations and integrate mesotherapy into a broader skin health strategy.

Bottom Line

Polynucleotide mesotherapy represents a regenerative approach to skin ageing — guiding your skin to repair and strengthen itself from within rather than relying solely on surface hydration or temporary volume. When applied judiciously by experienced professionals, it can be a powerful tool in the anti-ageing armoury.

If you’re serious about improving skin quality with measurable, biologically driven results, discuss polynucleotide mesotherapy as part of your tailored treatment plan at Julia Howard Skin Clinic.